The Role of Gut Microbiota in Inflammatory Bowel Disease: Current Insights and Future Directions
DOI:
https://doi.org/10.36676/ssjmra.v1.i2.12Keywords:
Inflammatory bowel disease (IBD), Gut microbiota, Crohn's disease (CD), Ulcerative colitis (UC), MicrobiomeAbstract
Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder of the gastrointestinal tract with a complex etiology. Emerging evidence suggests a pivotal role of the gut microbiota in the pathogenesis Pand progression of IBD. This review provides a comprehensive overview of the current understanding of the role of gut microbiota in IBD, highlighting recent insights from microbiome studies and their implications for disease management. Key topics include alterations in gut microbial composition and function in IBD patients, the interaction between the host immune system and gut microbiota, and the influence of environmental factors on the gut microbiome. Furthermore, we discuss potential therapeutic interventions targeting the gut microbiota, such as probiotics, prebiotics, antibiotics, fecal microbiota transplantation, and microbial-based therapies. Finally, we outline future directions for research aimed at elucidating the intricate relationship between gut microbiota and IBD pathogenesis, with the ultimate goal of developing novel therapeutic strategies for the management of this debilitating condition.
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