Understanding the Neurobiology of Depression: Implications for Novel Therapeutic Interventions


  • Dr. Karan Mehta Maulana Azad Medical College (MAMC), New Delhi




Depression, Neurobiology, Therapeutic interventions, Neurotransmitters, Neural circuits


Depression is a complex and debilitating mental health disorder that affects millions of people worldwide. Despite decades of research, our understanding of its neurobiological underpinnings remains incomplete. This review examines recent advances in the neurobiology of depression and their implications for the development of novel therapeutic interventions. Key neurobiological findings suggest that depression involves dysregulation of multiple neural circuits and neurotransmitter systems, including the monoaminergic pathways (serotonin, norepinephrine, and dopamine), the hypothalamic-pituitary-adrenal (HPA) axis, and the inflammatory response system. Structural and functional neuroimaging studies have identified alterations in brain regions involved in emotion regulation, such as the prefrontal cortex, amygdala, and hippocampus, as well as disruptions in neural connectivity patterns.


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DOI: 10.36676/ssjmra.v1.i2.15
Published: 02-07-2024

How to Cite

Dr. Karan Mehta. (2024). Understanding the Neurobiology of Depression: Implications for Novel Therapeutic Interventions. Shodh Sagar Journal for Medical Research Advancement, 1(2), 25–30. https://doi.org/10.36676/ssjmra.v1.i2.15



Original Research Article