Neuropharmacology of Addiction: Insights into Novel Treatment Approaches

Authors

  • Dr. Sanjay Mishra Psychiatrist, Bengaluru

DOI:

https://doi.org/10.36676/ssjmra.v2.i1.31

Keywords:

Neuropharmacology, Addiction, Substance dependence, Neurobiological, mechanisms

Abstract

Neuropharmacology of addiction encompasses a complex interplay of neurobiological mechanisms underlying substance dependence and addictive behaviors. current insights into the neurochemical and neuroadaptive changes associated with addiction, focusing on neurotransmitter systems such as dopamine, glutamate, and opioid receptors. Key topics include the role of reward pathways, neuroplasticity, and genetic factors in addiction vulnerability. Novel treatment approaches are also discussed, including pharmacotherapies targeting specific neurotransmitter systems to modulate craving, withdrawal symptoms, and relapse prevention. Emerging therapies, such as neurostimulation techniques and gene therapy, offer promising avenues for personalized treatment strategies tailored to individual addiction profiles.

References

Volkow, Nora D., and Ruben D. Baler. "Brain imaging biomarkers to predict relapse in alcohol addiction." Journal of the American Medical Association 311, no. 18 (2014): 1833-1834.

Koob, George F., and Nora D. Volkow. "Neurobiology of addiction: a neurocircuitry analysis." The Lancet Psychiatry 3, no. 8 (2016): 760-773.

Kalivas, Peter W., and Derek Van Bockstaele. "Neurobiology of cocaine addiction: implications for new pharmacotherapy." American Journal of Addiction 10, no. 3 (2001): 203-217.

Lüscher, Christian, and Antonello Bonci. "Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling." Neuron 69, no. 4 (2011): 650-663.

Kendler, Kenneth S., et al. "A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence." Psychological Medicine 36, no. 01 (2006): 31-40.

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Published

31-03-2025
CITATION
DOI: 10.36676/ssjmra.v2.i1.31
Published: 31-03-2025

How to Cite

Mishra, S. (2025). Neuropharmacology of Addiction: Insights into Novel Treatment Approaches. Shodh Sagar Journal for Medical Research Advancement, 2(1), 5–8. https://doi.org/10.36676/ssjmra.v2.i1.31

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Section

Original Research Article

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